MATH 4370
Spring 2004 (TR 3:00 - 4:20 pm, BH 143)

Tentative Schedule of Topics
(Revised 1/27/04)

Date
Topics
1/13   A primer in molecular genetics (Dr. Elizabeth Walsh)
1/15   A primer in molecular genetics, cont'd (Dr. Elizabeth Walsh)
1/20   Exercise 1: DNA, codons, translation, amino acids
1/22   Discussion: Gene prediction, codon usage
1/27   Exercise 2: Genome sizes and genome sequencing projects
1/29   Exercise 3: Retrieving data from public Databases
2/3   Development and challenges in bioinformatics
2/5   Sequence Alignment: Scoring similarity
2/10   Sequence Alignment: Dynamic programming algorithm,
  Exercise 4.
2/12   Sequence Alignment with EMBOSS, Exercise 5.
2/17   BLAST
2/19   Class Discussion
2/24   In class test
2/26   BLAST algorithm and statistics
3/2   BLOSUM matrix
3/4   In class exercise on random sequence model.
3/9   In class exercise on the chi-square statistics
3/11   In class exercise on estimation
3/16   Spring Break
3/18   Spring Break
3/23   Sequence Composition
3/25   Random sequence Models
3/30   Rolling die versus Markov sequence models
4/1   Theory of Markov chains
4/6   Theory of Markov chains
4/8   Overview of final project
4/13  Introduction to Microarrays
4/15  cDNA array data normalization
4/20  Affymetrix Data
4/22  Discussion of microarray data normalization
4/27   Student Presentation - Project A
4/29  Wrap-up
5/6  Written report for final project due